This week in T1D research

What is Via Negativa Research Bytes

The diabetes research literature is vast, noisy, and rarely written for the people who live with the condition or the clinicians who guide them. Via Negativa Research Bytes is the GNL answer to that. We read everything that lands in the GNL Scholar harvest each week, drop the off-topic noise, and surface only the small handful that change the conversation.

The page you are reading is the rolling weekly digest. It is overwritten every Wednesday with the new picks, so the URL stays stable and the latest is always the live page. Older weeks are archived locally in the GNL evidence base, where the GNL Grace engine can draw on them later.

Each pill below covers one topic area. Inside each pill we list the one or two papers picked for the week, with a plain summary and a short GNL takeaway. We do not give clinical advice. We point you at the evidence and at the relevant GNL guide or explorer where you can dig in.

AID and Automated Insulin Delivery

Safety and Effectiveness of MiniMed 780G Advanced Hybrid Closed-Loop Use with Ultrarapid Insulin Lispro-AABC in Pediatric and Adult Type 1 Diabetes

Akturk HK, Nally LM, Lal RA, Warren ML, et al. · Diabetes Technology and Therapeutics · 2026

GNL takeaway. Updates Pack 2 AID with the first paeds+adult URLi+AHCL real-world data; sharpens AID Optimiser positioning (ROS 100/2h is achievable safely) and paediatric guide Pack 9 (mealtime vs premeal URLi advantage in kids). Manufacturer-flagged.

Abstract. Multi-site (19), single-arm trial of MiniMed 780G AHCL with ultrarapid lispro-aabc (Lyumjev) in N=101 paediatric (7-17y) and N=110 adult T1D. After 3 months on URLi+AHCL, TIR exceeded predefined thresholds in both cohorts (paeds delta TIR +17.4 percent, adult +10.6 percent); A1c unchanged in paeds, fell in adults (7.4 to 6.9 percent, P<0.001). Use of recommended optimal settings (100 mg/dL target, 2h AIT) helped achieve targets. Most caregivers agreed mealtime vs premeal URLi simplified paediatric meal management. No severe hypoglycaemia or DKA.

DOI: 10.1177/15209156261444994 · GNL relevance 5/5

Nutrition and Carbohydrates

Quantifying the Effect of Fat and Protein on the Postprandial Glucose Excursion in Individuals With Type 1 Diabetes Using an Automated Insulin Delivery System

Faggionato E, Schiavon M, Ekhlaspour L, Kingman RS, et al. · Journal of Diabetes Science and Technology · 2026

GNL takeaway. Pack 8 (carb counting, just closed 5 May) gains a direct fat-protein quantitative reference; informs Hyper Treatment Explorer fat-protein response branch and AID Optimiser extended-bolus / split-bolus framing. Cohort skews paediatric (mean age 15.5).

Abstract. N=120 free-living T1D (mean age 15.5y, mean weight 51.3 kg) on CGM and CSII, 353 prandial traces classified by fat and protein content; Minimally-Invasive Oral Minimal Model (MI-OMM) used to estimate gastric retention, glucose rate of appearance, and insulin sensitivity. High fat and high protein content significantly slowed gastric retention and Ra (P<0.01) and reduced insulin sensitivity (P<0.05). Authors argue these results are usable for redesigning current insulin therapies for fat and protein.

DOI: 10.1177/19322968261440943 · GNL relevance 4/5

Exercise and Activity

Effect of breaking up sitting with regular active breaks on glucose management and vascular function in adults with type 1 diabetes who use hybrid closed-loop insulin delivery

Jenkins JG, Cocks M, Lucas SJE, Rendeiro C, et al. · BMJ Open Sport and Exercise Medicine · 2026

GNL takeaway. Watch-list. Pack 3 Exercise currently flags ‘sedentary-break evidence in HCL users is limited’; this trial directly fills that gap. Even as a protocol, the design (3 min walk every 30 min over 7h) is itself a teachable nudge in the Activity Explorer.

Abstract. UK randomised cross-over trial protocol (n=24 T1D adults on HCL, ISRCTN56375691). Each participant completes two 7h conditions: uninterrupted sitting (Sedentary) vs 3 min low-intensity walking every 30 min (Active Breaks). Primary outcome CGM glucose; secondary outcomes peripheral vascular function (flow-mediated dilation) and cerebral CO2 reactivity. Trial registered, ethics approved (London City and East REC, 25/PR/0098). Results not yet reported.

DOI: 10.1136/bmjsem-2026-003240 · GNL relevance 4/5

CGM and Continuous Glucose Monitoring

Impact of continuous glucose monitoring on fear of hypoglycemia and quality of life in children and adolescents with type 1 diabetes

Koprulu O, Karatas MC, Akbel S, Simsek FY, Erbas IM, et al. · Journal of Pediatric Endocrinology and Metabolism · 2026

GNL takeaway. Pack 1 CGM and Pack 9 Paediatric intersection. Gives Grace a citable anchor for the ‘does CGM ease parental and child hypo fear?’ question parents ask in clinic. Sensor-wear-time correlation is family-actionable.

Abstract. Prospective observational study of first-time CGM users with paediatric T1D (>=6 months CGM use). Validated Children’s Hypoglycaemia Index (CHI) total score fell significantly post-CGM (p=0.018), with significant reductions in ‘specific situations’ (p=0.044) and ‘behaviour’ subscales (p=0.025); ‘general fears’ unchanged. PedsQL diabetes module showed no significant change. FoH improvement was associated with higher sensor active use percentage (98.95 vs 93.0, p=0.039).

DOI: 10.1515/jpem-2025-0733 · GNL relevance 4/5

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Where this fits in the GNL system

Via Negativa Research Bytes is one input into the GNL evidence engine. The full evidence base lives in the GNL Grace knowledge graph, and you can question Grace directly via the app. The GNL explorers translate the evidence into interactive tools for AID, CGM, hypo and hyperglycaemia, exercise, and alcohol.

Open Grace · Browse the explorers · Listen to the podcast

Educational only, not medical advice. Always discuss changes in your diabetes management with your care team.